Vishal Lamba: DNA Methylation and Its Relationship to Disease

Vishal Lamba is an experienced scientist knowledgeable in genetics and pharmacology. In epigenetics, DNA methylation is a mechanism that is used by the cells to control gene expression. There are some different tools that exist to control gene expression in eukaryotes. The DNA methylation mechanism is most commonly used as a signaling tool that can fix the genes in the off position.

In recent years, researchers have been able to link abnormal DNA methylation to the appearance of diseases such as cancer, lupus, muscular dystrophy and numerous congenital defects. This information may play a major role in helping scientist and doctors develop specific therapies and help them better understand and prevent conditions that may develop during embryonic development. Understanding the relationship between DNA methylation and the development of disease will help scientist and doctors better treat their patients with personalized and precision medicine.

Vishal Lamba has been studying genetics and their relationship to the development of disease for several years. He earned his Doctoral of Philosophy at the University of Tennessee.


Vishal Lamba: Treating Hepatocellular Carcinoma

Vishal Lamba has spent his career studying pharmacotherapy and pharmacology as a research scientist. An area that he has interest in is how to use personalized medicine to improve treatment outcome in hepatocellular carcinoma. Hepatocellular carcinoma is a type of cancer that starts in your liver. This kind of cancer can be difficult to treat, but if caught early, it has a chance of being cured.

There are many treatments for those who have been diagnosed with hepatocellular carcinoma. Here are the treatments that you should discuss with your doctor to find the right one for your particular situation.

  • Radiation kills the cancer cells with the use of high-energy rays. With radiation therapy, you may experience numerous side effects including nausea and vomiting, and fatigue.
  • Chemotherapy drugs can be placed directly into your liver. A thin, flexible tube is put in the artery that leads to the liver, delivery a chemo drug combination and a drug that blocks the artery, starving the tumor of blood.
  • An alcohol injection uses a thin needle to inject the liver directly with alcohol to destroy the tumor.
  • With cryoablation, a thin metal probe is used to freeze the tumor, killing the cancer cells.
  • You can undergo surgery to remove the part of the liver that is infected.
  • If too much of your liver is affected with cancer, you may have to have a liver transplant.

To make sure you understand all your options, you’ll want to work closely with your doctor to design the right treatment plan for you. Vishal Lamba is a scientist who has been studying the use of personalized medicine in the treatment of numerous diseases including cancer.

Vishal Lamba: How Your Lifestyle Can Affect Epigenetics

Vishal Lamba is a successful research scientist who has spent his career studying biological mechanisms and the genetic components that turn a gene off or on, known as epigenetics. This particular field, explores the potentially heritable changes in gene expression, without changing the underlying sequence of DNA. Variations in the epigenetics are natural and happen often, but it can be influenced by a variety of factors. Your age, environment, lifestyle, and disease state can all affect the epigenetics.

As the field of epigenetics continues to grow, scientists are beginning to better understand how the environment and individual lifestyles can influence epigenetic change by directly interacting with the genome. The variations in the genome can be reflected throughout a person’s life and within later generations. Recent human epidemiological studies have found that environmental factors during the prenatal and early postnatal stages of life, can influence a person’s risk of developing certain chronic diseases later in life.

The advancement of technologies and increased knowledge of epigenetics over the last decade has allowed scientists to understand the relationship between gene regulation, epigenetic change, and human disease. With this understanding, doctors, and scientist, like Vishal Lamba, will be able to create target treatments for some illness.

Vishal Lamba: Using Personalized Medicine to Redefine Cancer Treatments

An accomplished research scientist, Vishal Lamba has extensive experience and knowledge in pharmacology and pharmacogenomics. He has spent much of his career looking at how individuals can benefit from personalized medicine. The field of personalized medicine has been growing rapidly over the last decade and is beginning to redefine how doctors can treat cancer. Unlike previous treatment options, doctors are now able to treat cancer based on the specific molecular and genetic makeup of the tumor.

When doctors analyze cancer tumors individually, they can determine which combination of drugs will be the best to combat the disease. Along with being able to target each tumor on an individual level, personalized medicine has the potential to decrease the toxic side effects often associated with cancer treatments of the past. The personalized treatment of cancer can take several forms. It can mean testing the individual’s particular cancer to determine if a specific treatment will work, analyzing the patient’s genetic makeup to see if they can handle a certain kind of medicine, and conducting genetic tests to figure out if they have certain genetic mutations that might make them more susceptible to developing cancer.

The advancement of personalized medicine allows patients to get more accurate treatments for their cancer, which might result in fewer side effects. Vishal Lamba has been studying genetic biology and has extensive knowledge of personalized medicine.

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Vishal Lamba: Composition Tips for Better Nature Photographs

Dr. Vishal Lamba is a scientist who grew up in India. Along with conducting research in the field of pharmacology and pharmacogenomics, he loves to get outside and photograph the beautiful landscapes of Gainesville, Florida. It has taken him years to develop his skills as a nature photographer. Here are five tips to help you take better nature photographs.

  1. Use visual elements to lead the viewer’s eye into the photo. Leading elements can be anything from lines to a progression of shapes. A powerful visual will use leading lines that stretch from the foreground to the background.
  2. Find a good foreground to add depth and punch to your image. A chaotic scene can be simplified when you provide a point of reference.
  3. Use repeating patterns to engage the eye. Visual repetition gets the viewer’s eyes moving, creating compositional energy and engaging interest.
  4. Use visual elements to emphasize your subject. Use framing to simplify and focus interest and light to focus the viewer.
  5. Find ways to create visual energy in your photo. You can use shapes or lines that point in opposite directions to convey a sense of energy.

Nature photography can be difficult to master. Dr. Vishal Lamba loves taking time away from his hectic research schedule to capture the beautiful world around him.

Vishal Lamba: Essential Study Tips for Ph.D. Students

As Dr. Vishal Lamba knows, earning a Ph.D. is not easy. Students pursuing a Ph.D. have their fair share of struggles ranging from finding motivation, to maintaining productivity, to coming up with scientifically sound ideas. If you’re just starting the process of pursuing your Ph.D., here are some essential study tips to help you succeed.

  1. Start writing as early as you can and make it a habit of writing frequently. Even if you don’t have a paper on the horizon it is important that you are documenting your progress. This includes what you did, how you did it, and the obstacles you encountered.
  2. Read lots of papers to get a clear overview of your field of research. To be successful it is important to know what research has already done so you can better understand where your own research fits in.
  3. Take time to read other materials, especially those that relate to time management, motivation, and creativity. These types of books will help you grow as a student and provide practical advice.
  4. Don’t cut corners. Cutting corners in your work can result in your reputation being damaged. Being sloppy in your research will come back to haunt you, so don’t cut corners, no matter the short-term benefit.

Earning your Ph.D. is a long process that will take years to complete. Follow these tips to help you make it through your program and find success. Dr. Vishal Lamba earned his Ph.D. in Pharmacogenomics from the University of Tennessee in Memphis.

Vishal Lamba: The Ethical Concerns of Gene Editing

As Vishal Lamba knows from first-hand experience, genome editing is here to stay. While this has many positive implications, being potentially able to cure certain diseases, there is also a potentially negative side, which raises ethical concerns.

  • Upgraded Babies

One of the potential benefits of targeted genome editing is helping fetuses deal with certain diseases and conditions, possibly before they are born. The problem with this is simple: who will be the regulatory force that can allow the family only to cure potential prenatal diseases, but not make the child taller or give him or her blue eyes instead of brown? Any gene editing beyond disease control invites talk about designed babies.

  • The Potential for Misuse Is Obviously High

The possibility of gene editing being misused is high. When parents see a scenario where doctors helped a child using CRISPR or another gene editing tool, and they happen to be wealthy, the temptation to have a custom child can easily increase. This can lead to scenarios in which even healthy parents who could give birth to healthy children opt for genetic editing, not because it’s necessary, but because it’s available. When people have the necessary resources for genetic editing, it is very hard to stop them, especially with something like CRISPR that promises to be a cheap and quick tool when it finally becomes widely available. This in turn could lead to side-effects which right now are not well understood.

What happens when a couple decides that they want a different kind of baby? What if the government sees this as an opportunity, simply because people are willing to pay a fortune? Professor Doudna talked about this in an article, where she described a similar scenario. Parents wanting to make their child healthier, better looking, may be willing to do anything to take advantage of genetic editing, but at the end of the day, it all boils down to regulations. Will CRISPR be heavily regulated in the early years? We don’t know yet, but regulating something as complex as gene editing is likely going to be a challenge.

  • It Could Be Hard to Regulate

What makes CRISPR so promising but also potentially frightening, is how readily available it projects to be. Since it is a cheap and quick tool or at the very least it will be, regulation seems like something that would be extremely hard, at least once the products and the treatments are already on the market.

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